Protective activity of different concentration of tea polyphenols and its major compound EGCG against whole body irradiation-induced injury in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1328-1331, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-285347
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the different concentrate of tea polyphenols (TP) and its compound for irradiation-protection and investigate its mechanism.</p><p><b>METHOD</b>To evaluate the radioprotective activity, mice were exposed to whole body gamma irradiation. TP 80 and TP 50 (50, 10 mg x kg(-1)) and its major constituent epigallocatechin gallate (EGCG) (50, 10 mg x kg(-1)) were administered after irradiation to examine its inhibition against irradiation-induced injury.</p><p><b>RESULT</b>This study indicate that in comparison with non-irradiated controls, irradiation resulted in a significant reduction the spleen index (spleen weight/body weight 100), haematological parameters (RBC, WBC and PLT), activity of superoxide dismutase (SOD), and increase of malondialdehde (MDA) level in 28 days. Oral administration of TP (50 mg x kg(-1)) shown the best effect on reducing the irradiation-induced injury on mice studied, and showed a protective effect against irradiation-induced haematological parameters (RBC, WBC and PLT), the spleen index and MDA level significant reduction, and antioxidase activity (SOD) decrease.</p><p><b>CONCLUSION</b>The results suggest that TP 50 mg x kg(-1) and EGCG have in vivo antioxidant potential and radioprotective activity against whole body gamma irradiation in mice. It may be concluded that TP (50% EGCG) possess good irradiation-protective and antioxidant effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenols
/
Radiation Injuries
/
Radiation-Protective Agents
/
Superoxide Dismutase
/
Flavonoids
/
Blood
/
Plant Extracts
/
Random Allocation
/
Catechin
/
Chemistry
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2010
Type:
Article
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