Evaluation on SMEDDS of effective parts from Jiaotai pills in vitro and in vivo / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the properties of self-microemulsifying drug delivery system (SMEDDS) of effective parts from Jiaotai pills, and evaluate the character on improving intestinal absorption in rat.</p><p><b>METHOD</b>The appearance, the morphology, the particle size, tape, the time of formulating micro emulsion, the content and the stability were investigated; Taken total alkaloid as index, the intestinal absorption were investigated by using in situ recirculation model and comparing the micro emulsion solution and reference solution, The T (relative percentage remained) and K(a) (absorption rate constant) were calculated.</p><p><b>RESULT</b>After self-microemulsified, the average diameter of microemulsion was 34.12 nm and the time of self-microemulsifying was less than 3 min. SMEDDS was stable in room temperature in 3 months. The microemulsion were stable in 0.1 mol x L(-1) HCl at 37 degrees C for 8 h. T and K(a) of total alkaloid in SMEDDS were much higher than in that of its reference (P < 0.01), and the former K(a) was 152.6% of versus reference.</p><p><b>CONCLUSION</b>SMEDDS might significantly improve the absorption of both poorly soluble and low biological availability drugs in the intestinal tract, and increase drug stability, which will be suitable for compound Chinese medicine.</p>