Immune response to HSP70-HBcAg(18-27) complex in HBV transgenic mice / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 28-31, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-285487
ABSTRACT
<p><b>OBJECTIVES</b>To study the cellular immune response to HSP70-HBcAg(18-27) complex in HBV transgenic mice.</p><p><b>METHOD</b>HSP70-HBcAg(18-27) complex was reconstituted in vitro, then it was injected into HBV transgenic mice to observe the cellular immune response. At the same time, we investigated whether HSP70-HBcAg(18-27) complex could generate antigen specific cytotoxic T lymphocyte responses in spleen cells.</p><p><b>RESULTS</b>Our results demonstrated that HSP70-HBcAg(18-27) complex increased levels of CD4+ and CD8+ T cells in the spleens and peripheral blood of HBV transgenic mice, and the complex also activated dendritic and natural killer cells.</p><p><b>CONCLUSION</b>HSP70-HBcAg(18-27) complex has an immunological antigenicity in raising the immunoresponse to chronic HBV infection in HBV transgenic mice. HSP70-HBcAg(18-27) complex might be considered as a candidate for further studies on its role as a therapeutic vaccine against chronic HBV infection in humans.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Mice, Transgenic
/
T-Lymphocytes, Cytotoxic
/
Hepatitis B virus
/
HSP70 Heat-Shock Proteins
/
Allergy and Immunology
/
Genetics
/
Hepatitis B Core Antigens
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2007
Type:
Article
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