Quantitative T2 mapping evaluates the repaired articular cartilage / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To evaluate the value of T2 mapping in monitoring the repaired cartilage after matrix-associated autologous chondrocyte implantation/transplantation (MACI/MACT).</p><p><b>METHODS</b>Four patients (10 plug cartilages) were examined three times by T2 mapping at 1, 3, and 6 months using a 3.0 Tesla MR scan system. Quantitative mean (full-thickness) T2 values were calculated in the transplanted area and control cartilage. Paired t-tests were used to compare the T2 values between transplanted and control cartilage. For analysis of longitudinal T2 values, one-way analyses of variance were performed among 1, 3, and 6 months after MACI.</p><p><b>RESULTS</b>The mean T2 values of the transplanted area at 1, 3, and 6 months after MACI were (82.40±15.23), (71.09±13.06), (53.80±4.86) ms, respectively. There were significant differences between the transplanted and control cartilage at 1 and 3 months (both P<0.01) after MACI, but not at 6 months (P=0.196). There were significant differences among T2 values of 1, 3, and 6 months after MACI in transplanted area (P=0.03).</p><p><b>CONCLUSION</b>T2 mapping provides a useful tool for monitoring the biochemical development of the transplanted cartilage and can be used to evaluate the cartilage repair noninvasively.</p>