Inhibition of HIV virus-like particles production by BST-2 / 病毒学报
Chinese Journal of Virology
;
(6): 319-325, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-286035
ABSTRACT
Recently, BST-2 has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1 and other enveloped viruses by tethering virus particles to the cell surface. Here, we showed that the production of HIV-1 virus-like particles was markedly inhibited by BST-2. Both the transient and stable expressing of BST-2 had the same function and Vpu rescued the release of HIV-1 VLP in the presence of human BST-2. Consistent with a direct tethering mechanism, we confirmed that proteolysis releases restricted virions and further showed that this removed the ectodomain of BST-2 from the cell surface.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virion
/
Virology
/
Virus Replication
/
Vero Cells
/
Antigens, CD
/
Down-Regulation
/
HIV Infections
/
Cell Line
/
Chlorocebus aethiops
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2011
Type:
Article
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