Temporal and spatial population dynamics of rabies virus isolates in China / 病毒学报
Chinese Journal of Virology
;
(6): 231-237, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-286049
ABSTRACT
In order to study phylogeography, population dynamics and molecular evolution of rabies viruses (RABVs) isolates from China, especially spatio-temporal dynamics, the timescale of RABVs evolution and its pattern of migration, we performed an extensive comparative analysis of RABV N gene sequence data, representing 167 isolates sampled from 20 provinces in a 78-year period (from 1931 through 2009). The available Chinese isolates could be divided into two distinct cladesPhylogroup clades I comprised Chinese group 1-4; Phylogroup clades II contained Chinese group 5-8. We found no evidence for positive selection (dN/dS>1) acting at any codon and found strong selective constraints for N gene. Bayesian Markov Chain Monte Carlo (MCMC) analysis suggested that the Chinese rabies viruses originated within the last 2000 years and the mean rates of nucleotide substitution for the N gene were approximately 4 x 10(-4) substitutions per site per year. The analyses of the spatial and spatio-temporal evolution indicated that RABV isolates from China migrated among different Provinces.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rabies virus
/
China
/
Monte Carlo Method
/
Evolution, Molecular
/
Phylogeography
/
Genetics
Type of study:
Health economic evaluation
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2011
Type:
Article
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