Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
;
(12): 104-107, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-286551
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between single nucleotide polymorphisms (SNPs) in DNA methyltransferase 1 (DNMT1) (rs12984523, rs16999593, and rs2228612) and noise-induced hearing loss (NIHL) in Chinese Han population.</p><p><b>METHODS</b>This case-control study consisted of 188 cases (case group) and 300 controls (control group) in the same working position, who were matched for age and gender. The cases had a binaural average high-frequency hearing threshold not less than 40 dB, and the controls had a binaural average high-frequency hearing threshold less than 40 dB. The genotypes at the three SNPs were determined by TaqMan probe.</p><p><b>RESULTS</b>TT genotype at DNMT1 rs2228612 is a risk factor for NIHL (adjusted OR = 1.69, 95% CI 1.14-2.52).</p><p><b>CONCLUSION</b>The study of Chinese Han population suggested that DNMT1 rs2228612 is associated with susceptibility to NIHL.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Auditory Threshold
/
Haplotypes
/
Case-Control Studies
/
Risk Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
DNA (Cytosine-5-)-Methyltransferases
/
DNA (Cytosine-5-)-Methyltransferase 1
/
Genetics
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2014
Type:
Article
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