Percutaneous Radiofrequency Ablation with Multiple Electrodes for Medium-Sized Hepatocellular Carcinomas
Korean Journal of Radiology
;
: 34-43, 2012.
Article
in English
| WPRIM
| ID: wpr-28657
ABSTRACT
OBJECTIVE:
To prospectively evaluate the safety and short-term therapeutic efficacy of switching monopolar radiofrequency ablation (RFA) with multiple electrodes to treat medium-sized (3.1-5.0 cm), hepatocellular carcinomas (HCC). MATERIALS ANDMETHODS:
In this prospective study, 30 patients with single medium-sized HCCs (mean, 3.5 cm; range, 3.1-4.4 cm) were enrolled. The patients were treated under ultrasonographic guidance by percutaneous switching monopolar RFA with a multichannel RF generator and two or three internally cooled electrodes. Contrast-enhanced CT scans were obtained immediately after RFA, and the diameters and volume of the ablation zones were then measured. Follow-up CT scans were performed at the first month after ablation and every three months thereafter. Technical effectiveness, local progression and remote recurrence of HCCs were determined.RESULTS:
There were no major immediate or periprocedural complications. However, there was one bile duct stricture during the follow-up period. Technical effectiveness was achieved in 29 of 30 patients (97%). The total ablation time of the procedures was 25.4 +/- 8.9 minutes. The mean ablation volume was 73.8 +/- 56.4 cm3 and the minimum diameter was 4.1 +/- 7.3 cm. During the follow-up period (mean, 12.5 months), local tumor progression occurred in three of 29 patients (10%) with technical effectiveness, while new HCCs were detected in six of 29 patients (21%).CONCLUSION:
Switching monopolar RFA with multiple electrodes in order to achieve a sufficient ablation volume is safe and efficient. This method also showed relatively successful therapeutic effectiveness on short-term follow up for the treatment of medium-sized HCCs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Iohexol
/
Tomography, X-Ray Computed
/
Prospective Studies
/
Catheter Ablation
/
Ultrasonography, Interventional
/
Carcinoma, Hepatocellular
/
Disease Progression
/
Contrast Media
/
Electrodes
/
Kaplan-Meier Estimate
Type of study:
Practice guideline
/
Observational study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Radiology
Year:
2012
Type:
Article
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