Novel methods and strategies for strain improvement / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 801-805, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-286640
ABSTRACT
Improvement of the productivity of industrial strains is an important field in micro-biology, because wild-type strains isolated from nature usually produce only a low level of antibiotics. Although random screening and simple rational screening are still effective without using genomic information, they are always time- and labor-consuming. With the broad application of recombinant DNA technology, protoplast fusion and X-omics, novel methods and strategies such as metabolic engineering, genome shuffling, system biology and system biotechnology, ribosome engineering, epigenetic modification are being exploited for the industry microbiology. In this review, we will focus on the progress of these novel methods and strategies for strain improvement in recent years.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacteria
/
Biotechnology
/
Industrial Microbiology
/
DNA, Recombinant
/
Genetic Engineering
/
Gene Expression Regulation, Bacterial
/
Technology, Pharmaceutical
/
Classification
/
DNA Shuffling
/
Genetics
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2009
Type:
Article
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