Characterization and biocompatibility of human-like collagen-hyaluronic acid scaffold for blood vessel / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 591-598, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-286668
ABSTRACT
Human-like collagen (HLC) was cross-linked with hyaluronic acid by genipin in different ratio. The concentrations of hyaluronic acid in the mixture were 0, 0.01%, 0.05% and 0.1%. The blood vessel tubular grafts were then fabricated by freeze-drying. Microstructure, element composite, mechanical properties, cytotoxicity grade, and biocompatibility of different vascular scaffold groups were studied by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), tensile test, burst pressure experiment, cytotoxicity experiment, endothelial cells planted in blood vessel scaffolds and hypodermic embedding of mice. The results showed that HLC-HA (0.05%) tubular scaffold exhibited interconnected well-distributed and porous structure and porosity of 94.38%; achieved the desirable mechanical property with stress of (1000.8 +/- 7.9) kPa and burst pressure of (1058.6 +/- 8.2) kPa, hypocytotoxicity, favourable cytocompatibility, hisocompatibility and disposition of degradation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Biocompatible Materials
/
Blood Vessels
/
Materials Testing
/
Chemistry
/
Adhesives
/
Collagen
/
Tissue Engineering
/
Iridoids
/
Biomimetic Materials
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2009
Type:
Article
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