Risk of Hip Fractures in Men with Alpha-Blockers: A Nationwide Study Base on Claim Registry
Journal of Bone Metabolism
;
: 29-32, 2015.
Article
in English
| WPRIM
| ID: wpr-28674
ABSTRACT
BACKGROUND:
Alpha-blocker can result in falling and fractures because of adverse effect such as orthostatic hypotension due to vasodilatory effect. We investigated the association between the alpha-blocker and the risk of osteoporotic hip fractures using a nationwide claim database.METHODS:
We identified 1,051,651 men 65 years of age or older who had prescription records of alpha-blocker from nationwide medical claim database, from 2007 to 2012. Alpha-blockers were classified as non-specific general (NSG), non-specific slow-release (NSSR), uro-specific general (USG), and uro-specific slow release (USSR).RESULTS:
Total of 6,553 hip fractures were observed. The incidences of hip fracture within 1 year were higher than those of the reference periods in all type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and decreased with time, regardless of type of alpha-blocker.CONCLUSIONS:
Use of alpha-blocker is associated with increased risk of hip fracture, especially in early use.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Registries
/
Incidence
/
Prescriptions
/
Hip
/
Hip Fractures
/
Hypotension, Orthostatic
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Bone Metabolism
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS