Expressions of DAPK3 and c-Myc in endometrial cancer and their relationship with the patients' prognosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 863-869, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-286884
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of DAPK3 and c-Myc and their prognostic value in endometrial carcinoma (EC).</p><p><b>METHODS</b>The expressions of DAPK3 and c-Myc were detected immunohistochemically in 132 surgical specimens. The relationship between DAPK3 and c-Myc protein expressions and the clinicopathological features of the patients was evaluated.</p><p><b>RESULTS</b>Immunohistochemical analysis revealed low DAPK3 expression in 60.61% (80/132) and high c-Myc expression in 53.79% (71/132) of the specimens of EC. Both DAPK3 expression and c-Myc expression were significantly correlated with FIGO stage (P=0.034 and 0.015, respectively) and lymph node metastasis (P=0.022 and 0.031, respectively). DAPK3 expression was closely correlated with the histological grade (P=0.027) and depth of myometrial invasion (P=0.011). Kaplan-Meier survival analysis indicated that patients with low DAPK3 expressions had a shorter overall survival rate than those with high DAPK3 expressions (P=0.023), while patients with high c-Myc expressions had poorer prognoses than those with low c-Myc expressions (P=0.002). Spearman correlation analysis showed that DAPK3 and c-Myc expressions were negatively correlated (P<0.001, r=?0.310). Multivariate analysis identified a high c-Myc expression as the independent predictor of the prognosis of EC (P=0.007).</p><p><b>CONCLUSIONS</b>A low expression of DAPK3 and a high expression of c-Myc are associated with aggressive and metastatic behaviors of EC, and their detection may help to predict the prognosis of the EC patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Survival Rate
/
Proto-Oncogene Proteins c-myc
/
Endometrial Neoplasms
/
Diagnosis
/
Kaplan-Meier Estimate
/
Death-Associated Protein Kinases
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2016
Type:
Article
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