The characteristics of opioid receptors distributed in the neurons of habenula / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To explore the types of receptors distributed in MHb and LHb.</p><p><b>METHODS</b>Recording the currents of potassium channels in Hb neurons isolated from the rats 10-15 days after birth. To distinguish the types of receptors distributed in MHb and LHb by using the agonists of mu receptor DAMGO, and sigma receptor DPDPE.</p><p><b>RESULTS</b>Two types of current of K+ channels were recorded, the transient rectifier and delayed rectifier potassium channels. DAMGO or DPDPE increased the intensity of current of K+ channels.</p><p><b>CONCLUSION</b>In MHb there was a higher density of sigma receptor, and in LHb a higher density of mu receptor distributed.</p>