The changes of IL-1 and NO levels in the testes of rats with experimental varicocele / 中华男科学杂志
National Journal of Andrology
;
(12): 125-126, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-287227
ABSTRACT
<p><b>OBJECTIVES</b>To evaluate the effects of varicocele (VC) on IL-1 and NO levels in testes of rats with VC.</p><p><b>METHODS</b>Male adult Wistar rats were divided into two groups randomly, VC group (n = 30) and pseudo-operation group (n = 20), and the levels of IL-1 and NO in the testes were determined and compared.</p><p><b>RESULTS</b>The levels of IL-1 and No of left tests in VC group were higher than those in pseudo-operation group, respectively(P < 0.01). While the levels of IL-1 and NO of right testes between two groups were not significantly different (P > 0.05). More over, the level of IL-1 correlated significantly with that of NO(r = 0.572, P < 0.01).</p><p><b>CONCLUSIONS</b>The results revealed that the changes of IL-1 and NO levels in the testes of rats with VC might be the reason which caused testes damage, disturbance of spermatogenesis and even infertility.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Testis
/
Varicocele
/
Interleukin-1
/
Rats, Wistar
/
Disease Models, Animal
/
Metabolism
/
Nitric Oxide
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2002
Type:
Article
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