The rat model of erectile dysfunction caused by cavernous nerve injury / 中华男科学杂志
National Journal of Andrology
;
(12): 120-121, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-287229
ABSTRACT
<p><b>OBJECTIVES</b>To identify rat cavernous nerve and establish a rat model of erectile dysfunction (ED) caused by injury of cavernous nerve.</p><p><b>METHODS</b>Twenty rats were undergone dissections. Cavernous nerves were identified with the aid of operating microscope and confirmed by electrical stimulation. Then, 42 experimental rats were randomized into 3 groups, including sham operated controls, unilateral and bilateral cavernous nerve ablation groups. Three weeks after surgery, rat models were evaluated with Apomorphine Test.</p><p><b>RESULTS</b>The major pelvic ganglion lies on either side of the dorsolateral lobes of the prostate. It includes 2 inflows, one called hypogastric nerve and another is pelvic nerve. The largest outflow is termed as cavernous nerve. Stimulus parameters which could induce obvious penile erection were 5 volts, frequency of 20 Hertz and duration of 5 milliseconds. Three weeks after surgery, apomorphine could induce penile erection of each rat in controls with mean (2.57 +/- 1.40) erections in 30 minutes, while there were no erections (0.00 +/- 0.00) either in unilateral or bilateral group.</p><p><b>CONCLUSIONS</b>The rat of larger ganglion and its cavernous nerve can be easily identified, obvious response to electrical stimulation, low cost of animal purchase, easy housing and availability made rat as an ideal animal for establishing ED model caused by cavernous nerve injury. In addition, our study showed in the early period of cavernous nerve injury, either unilateral or bilateral, all rats lost their erectile function.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Wounds and Injuries
/
Models, Animal
/
Erectile Dysfunction
/
Nerve Tissue
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2002
Type:
Article
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