Taohong Siwu decoction II inhibits the angiogenesis and the expressions of VEGF and KDR/FLK-1 in C57BL/6J mice bearing B16 melanoma / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1866-1869, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-287267
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Taohong Siwu decoction II on B16 melanoma in mice and the underlying mechanism.</p><p><b>METHOD</b>C57BL/6J mice bearing B16 melanoma were used in this study. The experimental groups were treated respectively with Taohong Siwu decoction II at doses of 2.5, 5 and 10 g x kg(-1) and cyclophosphamide at 0.05 g x kg(-1), Taohong Siwu decoction II at 10 g x kg(-1) plus cyclophosphamide at 0.025 mg x kg(-1). The tumor volume and weight, the expression of VEGF and KDR/FLK-1 and the amount of MVD were measured.</p><p><b>RESULT</b>The tumor volume and weight, the expression of VEGF and KDR/FLK-1 and the amount of MVD were reduced significantly after treatment with Taohong Siwu decoction II at the doses of 5 and 10 g x kg(-1) and Taohong Siwu decoction II combined with cyclophosphamide as compared with normal saline-treated group (P < 0.01).</p><p><b>CONCLUSION</b>Taohong Siwu decoction II can inhibit the growth of B16 melanoma in mice and attenuate the expressions of VEGF and KDR/FLK-1, suggesting that Taohong Siwu decoction II produces the antitumor effect via a possible antiagiogenisis mechanism.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Melanoma, Experimental
/
Drugs, Chinese Herbal
/
Random Allocation
/
Chemistry
/
Vascular Endothelial Growth Factor Receptor-2
/
Cell Line, Tumor
/
Vascular Endothelial Growth Factor A
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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