Chemical constituents from tuber of Cremastra appendiculata / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1827-1830, 2005.
Article
in Zh
| WPRIM
| ID: wpr-287278
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents from the tuber of the planted Cremastra appendiculata.</p><p><b>METHOD</b>The compounds were isolated by column chromatography over silica gel, Sephadex LH-20 and RP-HPLC, and their structures were elucidated on the basis of spectroscopic analysis.</p><p><b>RESULT</b>Eight compounds were isolated, and identified as cirrhopetalanthrin (I), 7-hydroxy-4-methoxyphenanthrene-2-O-beta-D-glucoside (II), 4-(2-hydroxyethyl)-2-methoxyphenyl-1-O-beta-D-glucopyranoside (III), tyrosol 8-O-beta-D-gluco-pyranoside (IV), vanilloloside (V), p-hydroxybenzaldehyde (VI), sucrose (VII), adenosine (VIII).</p><p><b>CONCLUSION</b>These compounds are isolated from this plant for the first time. All compounds were evaluated against human colon cancer (HCT-8), human hepatoma (Bel7402), human stomach cancer(BGC-823), human lung adenocarcinoma (A549), human breast cancer (MCF-7), and human ovarian cancer (A2780) cell lines, and cirrhopetalanthrin (I) showed non-selective moderate cytotoxicity with IC50 values of 8.4-13.3 micromol x L(-1), and other compounds were inactive.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Plants, Medicinal
/
Sucrose
/
Benzaldehydes
/
Adenosine
/
Chemistry
/
Plant Roots
/
Inhibitory Concentration 50
/
Orchidaceae
/
Cell Line, Tumor
Limits:
Humans
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article