Role of arsenolite on 8-isoprostane of asthmatic mice plasm / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1758-1760, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-287306
ABSTRACT
<p><b>OBJECTIVE</b>Through the establishment of mouse' ovalbumin- sensitized asthmatic model and the observation of the 8-Isoprostane of plasm, to evaluate the therapeutic effects of arsenolite on asthmatic mice.</p><p><b>METHOD</b>Forty-two healthy Kunming male mice were randomly divided into control group and experience groups, the latter were treated with dexamethasone, arsenolite. Lung function were tested, 8-isoprostane of plasm and WBC of BALF were measured.</p><p><b>RESULT</b>Lung function improved after treating with dexamethasone or arsenolite. The WBC of asthmatic mice were significantly higher than those in control group, and decreased after treating with dexamethasone or arsenolite; 8-Isoprostane of plasm in asthmatic mice was higher than that of control group, and decreased after treating with dexamethasone or arsenolite.</p><p><b>CONCLUSION</b>There is oxidant stress status in asthmatic mice. Arsenolite could lighten airway obstruction, reduce airway high response and redress oxidant stress status in asthmatic mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxides
/
Pharmacology
/
Arsenicals
/
Respiratory Function Tests
/
Asthma
/
Blood
/
Bronchoalveolar Lavage Fluid
/
Materia Medica
/
Dinoprost
/
Random Allocation
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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