Association study on the mitochondrial genome region np16181-16193 variation with type 2 diabetes mellitus / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 340-344, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-287394
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of the mitochondrial DNA region np16181-16193 variations with type 2 diabetes mellitus (T2DM).</p><p><b>METHODS</b>Blood samples of 199 unrelated T2DM patients and 205 normal controls were collected to detect the mitochondrial DNA region np16181-16193 variations by PCR and sequencing, and to analyze the association of the variations with the major clinical symptoms.</p><p><b>RESULTS</b>The mitochondrial DNA np16181-16193 region is a hypervariable area, with several polymorphisms. Four types of np16181-16193 region variations were found only in T2DM. The 1-hour postprandial blood glucose (P1BG) in the T2DM individuals with np16181-16193 region variations was significantly higher than those without variations (P<0.05), while there was no significant difference in other biochemical parameters (P>0.05).</p><p><b>CONCLUSION</b>The mitochondrial DNA np16181-16193 variations could not be regarded as a risk factor for T2DM.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
DNA, Mitochondrial
/
DNA Mutational Analysis
/
Sequence Analysis, DNA
/
Genetic Predisposition to Disease
/
Complementarity Determining Regions
/
Diabetes Mellitus, Type 2
/
Genome, Mitochondrial
/
Genetics
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article
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