Analysis on haplotypes of five HLA loci in southern Chinese Han population by sequence-based typing / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 228-232, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-287417
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the polymorphism and haplotypes of HLA-A, B, Cw, DRB1 and DQB1 loci in Chinese Han population.</p><p><b>METHODS</b>A total of 186 unrelated healthy individuals from southern China were analyzed by sequence-based typing. Two-, three-, and five-locus haplotypes were estimated using the Expectation Maximization Algorithm. RESULTST Twenty-eight alleles for the HLA-A locus, 49 HLA-B alleles, 24 HLA-C alleles, 29 HLA-DRB1 alleles and 20 HLA-DQB1 alleles were detected. The A*0207-B*4601(10.81%), A*3303-B*5801(6.14%), B*4601-DRB1*0901(6.22%), B*4001*-DRB1*0901(3.78%), DRB1*090-DQB1*0303 (12.16%) and DRB1*1202-DQB1*0301(8.38%), A*0207-B*4601-Cw*0102 (10.75%), A*3303-B*5801-Cw*0302 (5.14%), A*0207-B*4601-DR*0901(5.07%), A*3303-B*5801-DRB1*0301(2.96%), A*0207-B*4601-Cw*0102-DRB1*0901-DQB1*0303(4.87%) and A*1101-B*1301-Cw*0304-DRB1*1501-DQB1*0601(2.43%) were the most common haplotypes in the southern Chinese Han population.</p><p><b>CONCLUSION</b>The results have shown the characteristics of the five HLA loci haplotype distribution and provided more information in anthropology, disease association studies and transplantation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Base Sequence
/
HLA-B Antigens
/
HLA-DQ Antigens
/
HLA-DR Antigens
/
China
/
Population Groups
/
Alleles
/
Allergy and Immunology
/
Ethnology
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2009
Type:
Article
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