Research on the features of DNA damage in nasopharyngeal carcinoma patients of normal constitution and abnormal constitution and in high-risk population of nasopharyngeal carcinoma / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
; (12): 452-455, 2013.
Article
in Zh
| WPRIM
| ID: wpr-287536
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the features of DNA damage in nasopharyngeal carcinoma (NPC) patients of normal constitution and abnormal constitution and in high-risk population of NPC.</p><p><b>METHODS</b>Using single cell gel electrophoresis technique, the DNA damage of peripheral blood lymphocytes was detected in 28 healthy subjects, 27 in high-risk population of NPC, and 13 NPC patients at their first visits. The DNA damage was detected in the populations of normal constitution and of abnormal constitution. The tail length, the tail moment, and the tail DNA% were taken as the indices of DNA damage.</p><p><b>RESULTS</b>The tail length was (35.77 +/- 4.22) microm, the tail moment was (8.10 +/- 1.63) microm, and the tail DNA% was 57.48% +/- 4.63% in NPC patients. They were (15.25 +/- 4.15) microm, (5.01 +/- 1.92) microm, and 31.99% +/- 4. 11% in high-risk population of NPC. They were (14.31 +/- 3.64) microm, (4. 37 +/- 1.80) microm, and 29. 89% +/- 3. 15% in healthy subjects. There was statistical difference in the three indices among the three populations (P <0.05). In all the three populations, more DNA damage existed in those of abnormal constitution than in those of normal constitution (P <0.05).</p><p><b>CONCLUSIONS</b>Obvious instability of genetic materials exists in NPC patients, manifested as severe DNA damage of lymphocytes. In all the three populations, more DNA damage existed in those of abnormal constitution than in those of normal constitution.</p>
Full text:
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Index:
WPRIM
Main subject:
Body Constitution
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DNA Damage
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Carcinoma
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Case-Control Studies
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China
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Nasopharyngeal Neoplasms
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Epidemiology
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Diagnosis
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Genetics
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Medicine, Chinese Traditional
Type of study:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2013
Type:
Article