Study on solubilization effect of solid dispersion technology and inclusion technology on pulsatillae total saponins / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4061-4066, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-287639
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of solid dispersion technology and inclusion technology on dissolution performance of Pulsatillae total saponins, and preliminarily investigate its mechanism.</p><p><b>METHOD</b>The solid dispersion of Pulsatillae total saponins-PEG 4000 was prepared by the melting method. The inclusion compound of Pulsatillae total saponins-hydroxypropyl-beta-cyclodextrin ( HP-beta-CD) was prepared by the freeze-drying method. The properties of solid dispersion and inclusion compound were identified by using IR, DSC and NMR. And the dissolution of solid dispersion and inclusion compound were also determined by the small glass method.</p><p><b>RESULT</b>IR, DSC and NMR results showed the formation of solid dispersion and inclusion compound. In terms of the dissolution, the inclusion compound ranked first, which was followed by solid dispersion and bulk pharmaceutical chemicals.</p><p><b>CONCLUSION</b>The inclusion technology could significantly increase the dissolution of Pulsatillae total saponins, whereas the solid dispersion showed no notable solubilization effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Saponins
/
Solubility
/
Spectrophotometry, Infrared
/
Drugs, Chinese Herbal
/
Chemistry
/
Drug Compounding
/
Methods
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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