Advance in studies on traditional Chinese medicine on Abeta's scavenging effect / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 4020-4023, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-287648
ABSTRACT
Aggregation and accumulation of beta-amyloid peptide (Abeta) in brain tissues contribute to the pathogenesis of Alzheimer's disease. Therefore, the promotion of Abeta clearance is one of the key targets for preventing and treatment Alzheimer's disease. Studies proved that some traditional Chinese medicine (TCM) compounds and extracts could impact the activity of degrading enzyme in amyloid peptide, the transport of hemato encephalic barrier and the phagocytosis of microglial cells, promote Abeta clearance, and improve learning and memory of animal models with Alzheimer's disease. In this review, we made an summary for the relations between Abeta and Alzheimer's disease, the Abeta clearance mechanism and the clearance effect of traditional Chinese medicines.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood-Brain Barrier
/
Chemistry
/
Amyloid beta-Peptides
/
Microglia
/
Drug Therapy
/
Protein Multimerization
/
Alzheimer Disease
/
Medicine, Chinese Traditional
/
Metabolism
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS