Effects of cinnamyl aldehyde on cell cycle and relafeol proteins expression in NIH3T3 cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1692-1694, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-287863
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of Cinnamyl aldehyde (CA) on NIH3T3 cell cycle and explore the possible mechanism further.</p><p><b>METHOD</b>Flowcytometry was used for observing cell cycle distribution. Expressions of proliferation cell nuclear antigen (PCNA) and Cyclin D1 protein in NIH3T3 cells were assessed by immunocytochemistry.</p><p><b>RESULT</b>After culture with CA for 24 hours, the percentage of populations of S phase was enhanced by 3% (P < 0.05) and cell proliferation index (PrI, S + G2/M) was increased by 3.5% (P < 0.01) , but G2/M phase had no obvious changes. The expressions of Cyclin D1 and PCNA proteins were improved markly by CA compared with controlgroup (P < 0.01).</p><p><b>CONCLUSION</b>CA could promote more cells in G0/G1 phase into S phase, which may be related to the regulation of the expressions of PCNA and Cyclin D1.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Acrolein
/
Immunohistochemistry
/
Cell Cycle
/
Chemistry
/
S Phase
/
Proliferating Cell Nuclear Antigen
/
Cyclin D1
/
Cinnamomum
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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