Hypnotic effect of Chinese materia medica Cynanchum chinese in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1774-1776, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-287897
ABSTRACT
<p><b>OBJECTIVE</b>To study the central pharmacological effect of the water and chloroform-extract compounds from C. chinese in mice.</p><p><b>METHOD</b>The independent activity test and the hypnotic synergism test by sub-threshold hypnotic dosage of pentobarbital were employed to evaluate the central pharmacological effect of the extract-compounds, and the minimal neurotoxicity was evaluated by the rotorod test.</p><p><b>RESULT</b>the extract-compounds exhibited significant dose-related inhibition effect of the spontaneous motor activity in mice after intraperitoneal administration. And the two extract-compounds promoted the hypnotic effect by sub-threshold hypnotic dosage administration of pentobarbital, and produced ED50 value of 2.36 g kg (-1) and 0.75 g kg(-1), respectively. Also, both extract-compounds showed no neurotoxicity in the experiment.</p><p><b>CONCLUSION</b>The extract compounds from C. chinese showed inhibitional effect on CNS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pentobarbital
/
Pharmacology
/
Physiology
/
Plants, Medicinal
/
Sleep
/
Drugs, Chinese Herbal
/
Water
/
Random Allocation
/
Central Nervous System
/
Chemistry
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS