Effect of resveratrol on heart function of rats with adriamycin-induced heart failure / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1563-1565, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-287913
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effects of resveratrol (RES) on the heart function of the rats with adriamycin-induced heart failure.</p><p><b>METHOD</b>Thirty adult male SD rats were randomly divided into 5 groups normal control (NC) group, adriamycin (ADR) group, RESL + ADR group, RES(H) + ADR group and RES group. RES of 30, 120, 120 mg x kg(-1) x d(-1) was given intraperitoneally (ip) once a day for 3 days in RES(L) + ADR group, RES(H) + ADR group and RES group respectively. The other two groups were given the same amount of normal saline the same way. On the 4h day,ADR of 10 mg x kg(-1) was given intraperitoneally once to induce myocardium injury model. After twenty-four hours, the pathological and biochemical changes of the myocardium were examined.</p><p><b>RESULT</b>As compared with NC group, the MDA, NO and NOS of the ADR group were significantly higher (P < 0.05), and the SOD of the ADR group were markedly lower (P < 0.05). As compared with ADR group, the indexes in RES(L) + ADR group, RES(H) + ADR group were exactly opposing, and took on dose dependance (P < 0.05). Light microscopic morphometry of the heart samples of the rats in ADR + RES(L, H) groups revealed typical diminishing of damage.</p><p><b>CONCLUSION</b>RES can relieve the toxic effects of ADR on myocardium, and the cardioprotective effects may be correlated with its antioxidant activity and downregulation of NO.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Stilbenes
/
Superoxide Dismutase
/
Blood
/
Doxorubicin
/
Random Allocation
/
Rats, Sprague-Dawley
/
Nitric Oxide Synthase
/
Heart
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2007
Type:
Article
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