Application of fluorescent in situ hybridization in primary diagnosis of aplastic anemia by morphology / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 5-8, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-287962
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical application of fluorescent in situ hybridization (FISH) for the differential diagnosis of myelodysplastic syndromes (MDS) and aplastic anemia (AA).</p><p><b>METHODS</b>A FISH kit capable of detecting the chromosomal abnormalities related to MDS was used to analyze 94 patients who were suspected to have AA by bone marrow morphology.</p><p><b>RESULTS</b>Cytogenetic abnormalities were detected in 11 of the 94 patients, which included trisomy 8 (5 cases), 20q- (1 case) and -Y (1 case). There were 4 cases related to MDS, which included 3 cases of 5q-, in which 1 case carry 20q- at the same time, and 7q- (1 case). No significant difference was found between the MDS and AA groups in terms of age, sex or routine blood examination including absolute neutrophil count, hemoglobin content and platelet count.</p><p><b>CONCLUSION</b>FISH can detect certain cytogenetic abnormalities related to MDS in patients morphologically diagnosed as AA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Trisomy
/
Chromosomes, Human, Pair 7
/
Chromosomes, Human, Pair 8
/
Bone Marrow Cells
/
Chromosome Aberrations
/
In Situ Hybridization, Fluorescence
/
Cell Biology
/
Diagnosis
/
Genetics
/
Anemia, Aplastic
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2016
Type:
Article
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