Advances in research on the genetics of peripheral arterial disease / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 890-893, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-287965
ABSTRACT
Peripheral arterial disease (PAD) shows increasing morbidity and mortality. Clinical manifestations of PAD, such as intermittent claudication, rest pain and nonhealing ulcer, contribute to impaired quality of life, and ischemic stroke caused by PAD can be life-threatening. Unfortunately, PAD patients often receive suboptimal treatment, and pathogenesis of the disease is still unclear. Over the past decade, the evolving technology and interdisciplinary collaboration have enabled improvement of diagnosis and treatment for PAD. This review makes a brief summary of the current status and progress in genetics research on PAD, which included candidate gene studies, linkage analyses, genome-wide association studies, and applications and development prospects of epigenetics, mitochondrial DNA and other new technologies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
DNA, Mitochondrial
/
Risk Factors
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
MicroRNAs
/
Genome-Wide Association Study
/
Peripheral Arterial Disease
/
Genetics
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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