Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 855-860, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-287972
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of mitochondrial DNA 5178 C/A (Mt5178) polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes mellitus (T2DM) among ethnic Han Chinese through a case-control study.</p><p><b>METHODS</b>The Mt5178C/A polymorphism was determined by sequencing 1103 T2DM patients and 791 healthy controls. Logistic regression analysis was conducted to estimate odds ratios (OR) and 95% confidence intervals (CI). To confirm the results, a meta-analysis was conducted based on published literature on the association of Mt5178 variant with T2DM.</p><p><b>RESULTS</b>No significant association was found between the Mt5178C/A variant and T2DM either by our study or the meta-analysis which included eight published studies. Nevertheless, it was found that the T2DM patients with 5178C genotype were at a higher risk for nephropathy complication (OR=1.49, 95%CI 1.005-2.197, P<0.05) and at significantly lower risk for hypertension complication (OR=0.744, 95%CI 0.556-0.996, P<0.05) compared with those carrying a 5178A genotype.</p><p><b>CONCLUSION</b>No association was found between the Mt5178C/A polymorphism of mitochondrial ND2 gene with the increased risk of T2DM. However, the polymorphism may affect the development of nephropathy and hypertension complications among T2DM patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Triglycerides
/
Blood
/
Blood Glucose
/
DNA, Mitochondrial
/
Odds Ratio
/
Chemistry
/
Meta-Analysis as Topic
/
Cholesterol
/
Fasting
/
Sequence Analysis, DNA
Type of study:
Etiology study
/
Observational study
/
Systematic reviews
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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