Association of rs13405728 polymorphism of LHR gene with slow ovarian response / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 840-843, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-287975
ABSTRACT
<p><b>OBJECTIVE</b>To assess the association of rs13405728 polymorphism of luteinizing hormone receptor (LHR) gene with slow ovarian response during assisted reproductive technology (ART).</p><p><b>METHODS</b>Two hundred and thirty-six women were enrolled and grouped according to their genotypes. The rs13405728 polymorphism was genotyped by DNA sequencing.</p><p><b>RESULTS</b>No signifiicant difference was found in antral follicle count and anti-Mullerian hormone between the three genotypes (P>0.05). The incidence of slow response in genotype GG was lower than in the other two genotypes (P<0.05). There was no significant difference in the amount of follicle stimulating hormone required, the number of follicles ≥14 mm on human chorionic gonadotrophin day, oocytes, mature oocytes, available embryos, and the clinical pregnancy rate among the three genotypes (P>0.05). There was an independent correlation between slow ovarian response with the genotypes of rs13405728, the initial dose of gonadotropin, and the dose of luteinizing hormone required (P<0.05).</p><p><b>CONCLUSION</b>Rs13405728 of the LHR gene may be associated with slow ovarian response in ART. Various mechanisms may be involved in the poor response and slow response.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ovulation Induction
/
Receptors, LH
/
Fertilization in Vitro
/
Logistic Models
/
Sequence Analysis, DNA
/
Polymorphism, Single Nucleotide
/
Reproductive Techniques, Assisted
/
Ovarian Reserve
/
Gene Frequency
/
Genetics
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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