Progress of molecular genetics research on rheumatoid arthritis / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 728-733, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-287999
ABSTRACT
Rheumatoid arthritis (RA) is a chronic, inflammatory, autoimmune disorder that principally attacks flexible joints and synovia. The precise pathogenesis of RA remains unclear, and genetic factors probably play an important role in its etiology. In addition to genes from human leukocyte antigen (HLA) region, such as HLA-DRB, genes from non-HLA region, such as TIM-3, PTPN22, TRAF1/C5, STAT4, CCR5, PADI4 and FCGR2A may also contribute to its susceptibility. The advance in molecular genetics research on RA is reviewed here.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis, Rheumatoid
/
Receptors, IgG
/
Genetic Predisposition to Disease
/
Protein Tyrosine Phosphatase, Non-Receptor Type 22
/
HLA-DRB1 Chains
/
Exome
/
Hepatitis A Virus Cellular Receptor 2
/
Genetics
/
Membrane Proteins
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2015
Type:
Article
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