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Effect of continuous veno-venous hemofiltration on the plasma level of cytokines in patients with multiple organ dysfunction syndrome / 中华外科杂志
Chinese Journal of Surgery ; (12): 1197-1199, 2006.
Article in Chinese | WPRIM | ID: wpr-288623
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of CVVH on the plasma levels of TNF-alpha, IL-1, IL-6, IL-8 in patients with multiple organ dysfunction syndrome (MODS).</p><p><b>METHODS</b>Twenty-two patients with MODS were treated with continuous veno-venous hemofiltration (CVVH), venous and arterial blood samples were taken at 0, 1, 4, 8 hour following CVVH and ultrafiltration fluid samples were taken at 8 hour following CVVH. Arterial blood samples were used for blood gas analysis, venous blood samples and ultrafiltration fluid were used to measure the levels of cytokines by ELISA.</p><p><b>RESULTS</b>The plasma levels of TNF-alpha and IL-1 were significantly decreased following CVVH (P < 0.05). The IL-1, IL-6, IL-8 were detected in the ultrafiltration fluid and TNF-alpha was not. Heart rate decreased and mean arterial pressure (MAP) increased significantly 4 hrs after CVVH (P < 0.05). PaO(2)/FiO(2) increased significantly (P < 0.05). The APACHE II scores reduced after CVVH (P < 0.05). The reduction of APACHE II score and the elimination of cytokines were positively correlated with ultrafiltration flow rates</p><p><b>CONCLUSIONS</b>CVVH can remove some cytokines in plasma, reduce APACHEII score and improve hemodynamics and oxygenation in MODS. Moreover, higher volume hemofiltration has better effect on the elimination of cytokines and can further improve the prognosis of MODS.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Blood / Retrospective Studies / Cytokines / Interleukin-8 / Hemofiltration / Interleukin-6 / Interleukin-1 / Tumor Necrosis Factor-alpha / Metabolism Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Blood / Retrospective Studies / Cytokines / Interleukin-8 / Hemofiltration / Interleukin-6 / Interleukin-1 / Tumor Necrosis Factor-alpha / Metabolism Type of study: Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Surgery Year: 2006 Type: Article