Determination of plasma protein binding rate of isopropylidene-shikimic acid / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 255-257, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-288660
ABSTRACT
<p><b>OBJECTIVE</b>To study the plasma protein binding rate of isopropylidene-shikimic acid.</p><p><b>METHOD</b>The ultrafiltration was employed to determine the plasma protein binding rate of isopropylidene-shikimic acid. The plasma concentrations of isopropylidene-shikimic acid were measured by HPLC.</p><p><b>RESULT</b>The plasma protein binding rate of isopropylidene-shikimic acid with dog plasma at the concentration of 0.3, 0.15 g x L(-1) and 0.5 mg x L(-1) were (4.36 +/- 0.02)%, (4.12 +/- 0.19)% and (2.23 +/- 0.59)%, respectively. While the plasma protein binding rate of isopropylidene-shikimic acid with normal human plasma at the above concentrations were (11.23 +/- 0.01)%, (10.06 +/- 0.69)% and (9.72 +/- 0.59)%, respectively.</p><p><b>CONCLUSION</b>The binding rate of isopropylidene-shikimic acid with plasma protein is low.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Shikimic Acid
/
Species Specificity
/
Blood Proteins
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Alkenes
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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