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Intestinal absorption characteristics of gastrodigenin in rats / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 858-861, 2012.
Article in Chinese | WPRIM | ID: wpr-288690
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the intestinal absorption characteristics of gastrodigenin.</p><p><b>METHOD</b>In vitro everted gut sac model and in situ rat single-pass intestinal perfusion model were used to evaluate the absorption characteristics of gastrodigenin in the different intestinal segments. The concentrations of gastrodigenin in the samples were determined by Ultra Performance Liquid Chromatography (UPLC) method, and the relevant absorption parameters were calculated.</p><p><b>RESULT</b>In the everted gut sac tests, no significant difference of absorption among the four segments was observed. A positive correlation was found between drug concentration and the accumulated absorption amount (Q). At the concentration of 400 mg x L(-1), the Q of gastrodigenin in the duodenum, jejunum, ileum and colon were 224.33, 225.81, 233.18 and 189.25 microg, respectively. The in situ rat single-pass intestinal perfusion tests showed that there was also no significant difference of absorption among the four segments. The absorption rates (A) of gastrodigenin in the duodenum, jejunum, ileum and colon were 45.8%, 48.39%, 47.00%, 54.35%, respectively.</p><p><b>CONCLUSION</b>Gastrodigenin can be well absorbed via passive diffusion in the intestine. The absorption rates of gastrodigenin in the different intestinal segments show no regioselectivity.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Benzyl Alcohols / Pharmacokinetics / Chromatography, Liquid / Rats, Sprague-Dawley / Intestinal Absorption / Intestines / Medicine, Chinese Traditional / Metabolism / Methods Type of study: Diagnostic study / Prognostic study Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Perfusion / Benzyl Alcohols / Pharmacokinetics / Chromatography, Liquid / Rats, Sprague-Dawley / Intestinal Absorption / Intestines / Medicine, Chinese Traditional / Metabolism / Methods Type of study: Diagnostic study / Prognostic study Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2012 Type: Article