Effect of zedoary oil for cat D and cat K expression in A549 cell line / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 842-846, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-288693
ABSTRACT
<p><b>OBJECTIVE</b>To explore the Zedoary oil on A549 cell line of collagen deposition cat D and cat K expression.</p><p><b>METHOD</b>The A549 cell line were treat by Zedoary oil on four different concentrations (0, 40, 80, 120 mg x L(-1)) in different time. Dynamic changes of collagen in A549 cell using Picric-sirius red method. Cat D and Cat K expression of level were detected by using western blot.</p><p><b>RESULT</b>The collagen content showed that Zedoary oil had an inhibitory effect on the deposition of A549 cells. The results of western blot showed that the expression of cat D and cat K were up-regulated significangly in A549 cells of Zedoary oil groups compared with that in controls.</p><p><b>CONCLUSION</b>A549 cell of collagen deposition were reduced by Zedoary oil. The effects may due to the up-regulation of cat D and cat K.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plant Oils
/
Gene Expression Regulation, Neoplastic
/
Up-Regulation
/
Chemistry
/
Blotting, Western
/
Cathepsin D
/
Collagen
/
Curcuma
/
Cell Line, Tumor
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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