Comparison of effects of badu shengji san on rats with different injured skins / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 711-714, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-288723
ABSTRACT
<p><b>OBJECTIVE</b>To compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins.</p><p><b>METHOD</b>The injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity.</p><p><b>RESULT</b>Compared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise.</p><p><b>CONCLUSION</b>The renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Acetylglucosaminidase
/
Skin
/
Skin Ulcer
/
Urine
/
Wounds and Injuries
/
Staphylococcal Skin Infections
/
Retinol-Binding Proteins
/
Drugs, Chinese Herbal
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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