Taurine induces apoptosis in pulmonary artery smooth muscle cells / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of taurine on apoptosis in PASMCs, and whether the death-receptor pathway act in the mechanism.</p><p><b>METHOD</b>Culture the PASMCs, and divided the cells into control, SD. Acridine orange(AO) assay and western-blot analysis on the expression of Bax, Bcl-2, Procaspase-3 and Fas were used to study the mechanism.</p><p><b>RESULT</b>A major finding of this study is that the Tau effects many apoptosis index, such as increasing the expression of Bax and Fas, decreasing the expression of Procaspase-3, and Bcl-2, accrescencing the mitochondrial depolarization, causing the nuclear shrinkage, all these datas demonstrated that Tau induced the apoptosis in pulmonary artery smooth muscle cells through mitochondrial-dependent pathway.</p><p><b>CONCLUSION</b>Tau induces the apoptosis in pulmonary artery smooth muscle cells through death-receptor.</p>