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A cross-sectional survey of coagulation factor VIII inhibitor in children with hemophilia A / 中华儿科杂志
Chinese Journal of Pediatrics ; (12): 99-102, 2014.
Article in Zh | WPRIM | ID: wpr-288780
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the current situation of coagulation factor VIII (FVIII) inhibitor development in children with hemophilia A (HA) through a cross-sectional survey, and to explore the risk factors of inhibitor development in order to provide evidence for further prevention and management strategies.</p><p><b>METHOD</b>The clinical data of outpatients with hemophilia A in Beijing Children's Hospital seen from November 2012 to May 2013 were collected, FVIII inhibitor was screened and analyzed its risk factors.</p><p><b>RESULT</b>A total of 102 HA children were enrolled, 5 were mild cases, 32 were moderate, and 65 were severe cases; the median age on enrollment was 55.5 (3.0-200.0) months:19(18.6%) of patients had inhibitors and 9 (8.8%) had low-titer inhibitors, 10 (9.8%) had high-titer inhibitors. Receiving FVIII treatment for life-threatening bleeding (P = 0.03) ,OR 4.10 (95%CI:1.17-14.32) was a risk factor for inhibitor generation and patients within 20 exposure days have more chances of inhibitor development (P = 0.04) ,OR 3.32 (95%CI:1.02-10.86) . High and intense FVIII exposure within short term was the risk factor for high titer inhibitor development (P = 0.01) ,OR 5.25 (95%CI:1.45-21.92) .</p><p><b>CONCLUSION</b>Intense FVIII exposure for severe hemorrhage was the risk factor of inhibitors development especially of high titer inhibitors.</p>
Subject(s)
Full text: 1 Index: WPRIM Main subject: Therapeutics / Time Factors / Blood / Factor VIII / Cross-Sectional Studies / Multivariate Analysis / Risk Factors / Blood Coagulation Factor Inhibitors / Dose-Response Relationship, Drug / Hemophilia A Type of study: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Zh Journal: Chinese Journal of Pediatrics Year: 2014 Type: Article
Full text: 1 Index: WPRIM Main subject: Therapeutics / Time Factors / Blood / Factor VIII / Cross-Sectional Studies / Multivariate Analysis / Risk Factors / Blood Coagulation Factor Inhibitors / Dose-Response Relationship, Drug / Hemophilia A Type of study: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Zh Journal: Chinese Journal of Pediatrics Year: 2014 Type: Article