Immunohistochemical study of heme oxygenase-1 expressed in human normal dental pulp cell and tissue / 华西口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the expression of heme oxygenase-1 (HO-1) in dental pulp tissue and to find out the relationship of distribution and function of HO-1.</p><p><b>METHODS</b>30 pulp tissues were obtained from clinically extracted human healthy premolars and third molars. The expression of HO-1 in dental pulp was detected by means of SABC immunohistochemical technology.</p><p><b>RESULTS</b>HO-1 immunoreactivity was observed in vascular endothelial cells, odontoblasts and some fibroblasts cells.</p><p><b>CONCLUSION</b>The distribution of HO-1 in normal human dental pulp suggests that HO-1 may play an important role in pulp flow regulation, dentin production and its calcifying; it also may play some roles in dental pulp cells metabolism and differentiation.</p>