The effect of oral carcinoma-associated fibroblasts on the invasion of carcinoma cell line / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 101-103, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-288995
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of oral carcinoma-associated fibroblasts (CAFs) on the invasion of a lingual carcinoma cell line, and to elucidate the role of CAFs in oral squamous cell carcinoma (OSCC) progression.</p><p><b>METHODS</b>Matrigel was used to remodel the basement memberane, and the interaction model between primary oral CAFs and lingual carcinoma cell line Tca8113 was established by Transwell chamber to observe the effect of CAFs on the invasion of Tca8113.</p><p><b>RESULTS</b>Compared with normal fibroblasts (NFs), CAFs promoted more Tca8113 cells to penetrate Matrigel (P < 0.05).</p><p><b>CONCLUSION</b>Oral CAFs can promote the invasion of lingual carcinoma cell line Tca8113, and play a key role in OSCC progression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mouth Neoplasms
/
Tongue Neoplasms
/
Carcinoma, Squamous Cell
/
Cell Line
/
Cell Line, Tumor
/
Cell Proliferation
/
Fibroblasts
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS