An experimental study of the inhibitory effects of Tripterygium extract (LLZ) on hypertrophic scar - derived fibroblasts / 中华烧伤杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the effects of Tripterygium extract (LLZ) on postburn hypertrophic scar - derived fibroblasts, so as to provide us an experimental support for the treatment of postburn hypertrophic scar.</p><p><b>METHODS</b>Hypertrophic scar - derived fibroblasts were harvested and cultured in vitro. A serial concentrations of LLZ (5 x 10(-3), 5 x 10(-4), 5 x 10(-5), 5 x 10(-6) g/L) were added to the culture media. The cellular morphology, proliferating activity and the cytotoxicity of the drug were observed after 24 hours of culture.</p><p><b>RESULTS</b>The fibroblast morphology could be altered by any concentration of LLZ solution. Furthermore, the cell count and the cellular proliferating activity were all decreased obviously by the treatment of LLZ.</p><p><b>CONCLUSION</b>The cell morphology and proliferation activity of postburn scar-derived fibroblasts could all be inhibited by LLZ, and it was the result of its toxic effects.</p>