The influence of N-acetyl-L-cysteine on pulmonary injury and oxygen stress after smoke inhalation injury / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 152-154, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-289222
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of N-acetyl-L-cysteine (NAC) on pulmonary injury and oxygen stress caused by smoke inhalation injury.</p><p><b>METHODS</b>Rats inflicted with smoke inhalation injury were employed as the model. WBC in BALF (bronchoalveolar lavage fluid), MPO (myeloperoxidase) activity, hydrogen peroxide (H(2)O(2)) content, GSH (glutathione) content and total antioxidant (TAO) capacity in pulmonary tissue were determined.</p><p><b>RESULTS</b>Postinjury WBC in BALF, MPO activity in pulmonary tissue and H(2)O(2) content decreased obviously after NAC treatment. But the pulmonary tissue contents of GSH and ATO increased evidently after the treatment with NAC.</p><p><b>CONCLUSION</b>NAC treatment could ameliorate pulmonary oxygen stress after smoke inhalation injury. AS a result, the pulmonary antioxidant capacity was improved.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Acetylcysteine
/
Bronchoalveolar Lavage Fluid
/
Smoke Inhalation Injury
/
Free Radical Scavengers
/
Rats, Wistar
/
Peroxidase
/
Oxidative Stress
/
Disease Models, Animal
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2002
Type:
Article
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