Effects of different excipients on properties of Tongsaimai mixture and pellet molding / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study preliminarily on the relationship between properties of the mixture composed of Tongsaimai extract and different excipients and pellet molding.</p><p><b>METHOD</b>The multivariate regression analysis was used to investigate the correlation of different mixture and pellet molding by measuring the cohesion, liquid-plastic limit of mixture, and the powder properties of pellets. The weighted coefficients of the powder properties were determined by analytic hierarchy process combined with criteria importance through intercriteria correlation.</p><p><b>RESULT</b>The results showed that liquid-plastic limit seemed to be a major factor, which had positive correlation with pellet molding, while cohesion had negative correlation with pellet molding in the measured range.</p><p><b>CONCLUSION</b>The physical properties of the mixture has marked influence on pellet molding.</p>