Effects of Naoxinduotai capsule on markers of prothrombotic state in patients with essential hypertension / 中国中药杂志
Zhongguo Zhong Yao Za Zhi
; (24): 3382-3385, 2010.
Article
in Zh
| WPRIM
| ID: wpr-289443
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of Naoxinduotai capsule on the markers of prothrombotic state as plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor (vWF) and alpha-granular membrane protein (CD62p) in essential hypertension patients of yang hyperactivity and blood stagnation.</p><p><b>METHOD</b>The 62 essential hypertension patients of yang hyperactivity and blood stagnation were divided into Naoxinduotai capsule + perindopril group (treatment group, 30 subjects) and Perindopril group (control group, 32 subjects). Clinical symptoms, blood pressure and the blood plasma PAI-1, vWF, CD62p of the patients were observed. The blood plasma PAI-1, vWF and CD62p were measured by enzyme-linked immunosorbant assay (ELISA).</p><p><b>RESULT</b>After 8 weeks treatment, in treatment group the clinical symptoms became better, and there was a significant difference with control group (P < 0.05). Blood pressure was significantly degraded, but there was not a significant difference with control group. The blood plasma PAI-1, vWF, CD62p level was degraded ,and there were significant differences with control group in all the three makers (P < 0.05).</p><p><b>CONCLUSION</b>Naoxinduotai capsule can treat the essential hypertension patients of Yang hyperactivity and blood stagnation, and it has conspicuous advantages in improving the clinical symptoms and the makers of prothrombotic state.</p>
Full text:
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Index:
WPRIM
Main subject:
Thrombosis
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Blood
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Blood Pressure
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Capsules
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Platelet Membrane Glycoproteins
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Biomarkers
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Treatment Outcome
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Plasminogen Activator Inhibitor 1
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P-Selectin
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Drug Therapy
Limits:
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Year:
2010
Type:
Article