Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 100-106, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-289458
ABSTRACT
The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application of BM-MSCs in the treatment of acquired AA. An increasingly number of laboratory statistics has demonstrated that the defectiveness of BM-MSCs is more likely to play an important role in the pathogenesis of AA, namely, the apparently different biological characteristics and gene expression profiles, the decreased ability of supporting hematopoiesis as well as self-renewal and differentiation, and the exhaustion of regulating immune response of hematopoietic environment. Those abnormalities continuously prompt AA to become irreversible bone marrow failure along with the imbalanced immunity. With deepening research on MSCs, infusion of MSCs for the primary purpose of recovering hematopoietic microenvironment may become a new approach for the treatment of AA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Therapeutics
/
Bone Marrow
/
Lymphocyte Activation
/
Cell Differentiation
/
Cytokines
/
T-Lymphocytes, Regulatory
/
Mesenchymal Stem Cell Transplantation
/
Cell Proliferation
/
Allergy and Immunology
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2015
Type:
Article
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