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Nasopharyngeal carriage rate, antimicrobial resistance and serotype distribution of Streptococcus pneumoniae among children with upper respiratory infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 988-992, 2014.
Article in Chinese | WPRIM | ID: wpr-289549
ABSTRACT
<p><b>OBJECTIVE</b>To investigate nasopharyngeal carriage rate, antimicrobial resistance and serotype distribution of Streptococcus pneumoniae among children with upper respiratory infection.</p><p><b>METHODS</b>Nasopharygeal swabs were collected from children with upper respiratory infection visiting the outpatient department of Beijing Children′s Hospital between March 2013 and February 2014. The antibiotic susceptibility was tested by Etest method, and the serotype was determined by Quellung reaction.</p><p><b>RESULTS</b>The nasopharyngeal carriage rate for Streptococcus pneumoniae was 23.8% (699/2 941). One hundred isolates were randomly chosen for antimicrobial susceptiblity test and serotyping. Up to 98.0% isolates were susceptible to parenteral penicillin. The susceptible rate against oral penicillin, however, was 33.0%. The non-susceptible rate to erythromycin and azithromycin was 97.0%. The multi-drug resistance rate was up to 86.0%. The common serotypes were 6A(12.0%), 19F(12.0%), 6B(10.0%), 23F(9.0%) and 14(8.0%). The coverage rates of 7-, 10- and 13-valent pneumococcal conjugate vaccine were 41.0%, 42.0% and 59.0% respectively.</p><p><b>CONCLUSIONS</b>About 25% of children with upper respiratory infection are nasopharyngeal colonized by Streptococcus pneumoniae. The isolates show a high antimicrobial resistance. The 13-valent pneumococcal conjugate vaccine covers about 60.0% of the isolates.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Respiratory Tract Infections / Streptococcus pneumoniae / Carrier State / Serotyping / Nasopharynx / Epidemiology / Classification / Pneumococcal Vaccines / Drug Resistance, Bacterial / Allergy and Immunology Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Respiratory Tract Infections / Streptococcus pneumoniae / Carrier State / Serotyping / Nasopharynx / Epidemiology / Classification / Pneumococcal Vaccines / Drug Resistance, Bacterial / Allergy and Immunology Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2014 Type: Article