Correlation between Chlamydia pneumoniae infection and chronic obstructive pulmonary disease / 中华流行病学杂志

ABSTRACT

Objective To investigate the correlation between Chlamydia pneumonia (Cpn)infection and chronic obstructive pulmonary disease (COPD).Methods 82 patients with acute exacerbation COPD (AE-COPD) or stabilized COPD patients at outpatient visits,in the People' s Hospital of Jiangyin city from Aug.2010 to May 2012,together with 46 cases having stationary phase COPD and 38 healthy volunteers as control group,were involved in this study.Patients were bled 2 ml,on the next day of hospitalization while patients at emergency room were bled 2 ml immediately,but bled again on the 15th day.Serum was separated through cryopreservation and the Cpn antibodies (IgG,IgM and IgA antibodies) were detected,under micro-immunofluorescence.Results In terms of IgG in the three groups,the positive rates did not show significant differences (P＞0.05) but the GMT of the IgG in the AE-COPD group was significantly higher (P＜0.01) than that in the control group.IgA positive rate among the three groups; AE-COPD appeared the highest.There was no significant difference between the AE-COPD group and stationary phase COPD group (P＞0.05),however,there were significant differences between the AE-COPD group,the stationary phase COPD group and the control group (P＜0.01).In terms of GMT of IgA in the three groups,there was significant difference between the AE-COPD group and stationary phase COPD group (P＞0.05),but with significant difference between the AE-COPD group and the control group (P＞0.01).There was significant difference between stationary phase COPD group and the control group (P＞0.05).When comparing both the rates of acute infection and chronic infection on the AE-COPD groups with the control group,there appeared significant differences (P＜0.05,P＜0.01).When comparing the acute and chronic infection between the stationary phase COPD group and the control group,the rate of acute infection did not show significant difference (P＞0.05) while the chronic infection rate appear to have had significant difference (P＜0.01).Conclusion Cpn infection seemed to be closely related to the development of COPD.