Research Advances in CKLFSF-like MARVEL Transmembrane Domain Containing Member 3 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 360-363, 2016.
Article
in English
| WPRIM
| ID: wpr-289855
ABSTRACT
CKLF-like MARVEL transmembrane domain containing member/chemokine-like factor super family member (CKLFSF/CMTM) is a novel tumor suppressor gene. CMTM3 is broadly expressed in normal human tissues and evolutionary conserved,especially in testis,spleen,and some cells of peripheral blood mononuclear cells. However,its expression is undetectable or down-regulated in most carcinoma cell lines and tissues. Restoration of CMTM3 may inhibit the proliferation,migration,and invasion of carcinoma cells. Although the exact mechanism of its anti-tumor activity remains unclear,CKLFSF3/CMTM3 is closely connected with immune system and associated with sex during tumorigenesis. The study advances of CKLFSF3/CMTM3 are elaborated in this review as CMTM3 may be a new target in the gene therapies for tumors,especially genitourinary tumors,while further studies on CMTM3 and its anti-tumor mechanisms are warranted.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Leukocytes, Mononuclear
/
Down-Regulation
/
Cell Transformation, Neoplastic
/
Chemokines
/
MARVEL Domain-Containing Proteins
/
Genetics
/
Neoplasms
Limits:
Humans
/
Male
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2016
Type:
Article
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