Expression Patterns of the Proteins Associated with Cell Junctions in Mouse Testes / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 205-209, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-289880
ABSTRACT
<p><b>OBJECTIVE</b>To study on the expression patterns of proteins associated with cell junctions in the developing mouse testes.</p><p><b>METHOD</b>The expression levels of reproductive related cell lines spermatogonia cell line GC1 spg, spermatocyte cell line GC2 spg, leydig cell line TM3, and sertoli cell line TM4, primary sertoli cells, and 1-6-week mouse testes were analyzed using Western blot.</p><p><b>RESULTS</b>The sertoli cell junction-associated membrane proteins adhesion molecule A, Occludin and Claudin, and the sertoli-germ cell junction-associated membrane proteins junctional adhesion molecule C, Nectin-3, and E-cadherin were stage-specific in the seminiferous tubules in the mouse testes. The adaptor proteins associated with cell juctions zonula occludens-1, zonula occludens-2, Afadin, Β-catenin, and CD2-associated protein were not stage-specific in the seminiferous tubules in the mouse testes.</p><p><b>CONCLUSIONS</b>In the seminiferous tubules in the mouse testes, the membrane proteins associated with cell junctions are stage-specific. However, the expressions of adaptor proteins associated with cell junctions do not obviously change.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seminiferous Tubules
/
Sertoli Cells
/
Testis
/
Cell Adhesion Molecules
/
Cell Line
/
Cell Biology
/
Cytoskeletal Proteins
/
Adaptor Proteins, Signal Transducing
/
Beta Catenin
/
Zonula Occludens-1 Protein
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2016
Type:
Article
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