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Human Umbilical Cord-derived Mesenchymal Stem Cells Secrete Interleukin-6 to Influence Differentiation of Leukemic Cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 164-168, 2016.
Article in Chinese | WPRIM | ID: wpr-289887
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of human umbilical cord-derived mesenchymal stem cells (UC-MSC) on the differentiation of leukemic cells.</p><p><b>METHODS</b>The co-culture system of UC-MSC with acute promyelocytic leukemic cell line NB4 cells was constructed in vitro,and the differentiation status of the leukemic cells was assessed by cell morphology,nitroblue tetrazolium reduction test,and cell surface differentiation marker CD11b.</p><p><b>RESULTS</b>UC-MSC induced the granulocytic differentiation of NB4 cells. When UC-MSC and a small dose of all-trans retinoic acid were applied together,the differentiation-inducing effect was enhanced in an additive manner. Interleukin (IL)-6Ra neutralization attenuated differentiation and exogenous IL-6-induced differentiation of leukemic cells.</p><p><b>CONCLUSION</b>UC-MSC can promotd granulocytic differentiation of acute promyelocytic leukemia cells by way of IL-6 and presented additive effect when combined with a small dose of all-trans retinoic acid.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Tretinoin / Umbilical Cord / Leukemia, Promyelocytic, Acute / Cell Differentiation / Interleukin-6 / Cell Biology / Cell Line, Tumor / Mesenchymal Stem Cells Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Tretinoin / Umbilical Cord / Leukemia, Promyelocytic, Acute / Cell Differentiation / Interleukin-6 / Cell Biology / Cell Line, Tumor / Mesenchymal Stem Cells Limits: Humans Language: Chinese Journal: Acta Academiae Medicinae Sinicae Year: 2016 Type: Article